Benzyloxazolidine-2, 4-diones as potent hypoglycemic agents

…, BM Bechle, TT Chou, DA Clark, B Hulin…

Index: Dow; Bechle; Chou; Clark; Hulin; Stevenson Journal of Medicinal Chemistry, 1991 , vol. 34, # 5 p. 1538 - 1544

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Citation Number: 79

Abstract

A series of benzyloxazolidine-2, 4-diones, containing oxazole-based side chains, were found to lower blood glucose levels in the genetically obese ob/ob mouse. Incorporation of a benzofuran structural element in these compounds provides greatly enhanced in vivo potency. The syntheses and structure-activity relationships for this series are detailed.

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