Synthesis and evaluation of RGD peptidomimetics aimed at surface bioderivatization of polymer substrates

…, R Touillaux, G Dive, J Marchand-Brynaert

Index: Boxus, Thierry; Touillaux, Roland; Dive, Georges; Marchand-Brynaert, Jacqueline Bioorganic and Medicinal Chemistry, 1998 , vol. 6, # 9 p. 1577 - 1595

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Citation Number: 44

Abstract

Several RGD peptidomimetics have been prepared, in a convergent way, from the common ortho-amino-tyrosine template (O-substituted with an anchorage-arm or a methyl group, and αN-substituted with a fluorine tag for XPS analysis), and various ω-aminoacid derivatives. The most flexible compounds have shown a biological activity similar to that of the peptide reference (RGDS) in the platelet aggregation test. The compound 16a could be fitted (by ...