Palladium-catalysed alkynylations of 2-pyrone (pyran-2-one) halides

IJS Fairlamb, FJ Lu, JP Schmidt

Index: Fairlamb, Ian J. S.; Lu, Feng Ju; Schmidt, Jan Peter Synthesis, 2003 , # 16 p. 2564 - 2570

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Citation Number: 23

Abstract

Abstract The 2-pyrone sub-unit is found in a large number of natural products possessing broad-spectrum biological activity. As such, efficient synthetic methods are required to enable facile access to substituted 2-pyrone derivatives. Important conditions for the Sonogashira alkynylation of 4-bromo-6-methyl-2-pyrone (3a) have been developed, and compared against Negishi's methodology. The best conditions for Sonogashira ...