Tetrahedron letters

A practical preparation of 5-(ketoaryl) thiazoles

KM Marcantonio, LF Frey, JA Murry, C Chen

Index: Marcantonio, Karen M.; Frey, Lisa F.; Murry, Jerry A.; Chen, Cheng-Yi Tetrahedron Letters, 2002 , vol. 43, # 49 p. 8845 - 8848

Full Text: HTML

Citation Number: 36

Abstract

This article describes a facile synthesis of 2-substituted-5-(ketoaryl) thiazoles, which are important intermediates for the synthesis of biologically active compounds. A variety of 2- substituted thiazole anions were added to aryl nitriles to provide the desired ketones after aqueous hydrolysis.