Studies on quinoline derivatives and related compounds. 5. Synthesis and antimicrobial activity of novel 1-alkoxy-1, 4-dihydro-4-oxo-3-quinolinecarboxylic acids

H Agui, T Mitani, A Izawa, T Komatsu…

Index: Agui,H. et al. Journal of Medicinal Chemistry, 1977 , vol. 20, p. 791 - 796

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Citation Number: 53

Abstract

A series of novel l-aIkoxy-l, 4-dihydr~ 4-oxo-3-quinolinecarboxylic acids was synthesized and screened as antimicrobial agents. The most active compounds in vitro against gram- negative microorganisms and Staphylococcus aureus were 1, 4-dihydro-l-methoxy-6, 7- methylenedioxy-4-oxo-3-quinolinecarboxylic acid (22), 1, 2, 6, 9-tetrahydro-6-methoxy-9- oxofuro [3, 2-flquinoline-8-carboxylic acid (30), and 2, 3, 6, 9-tetrahydro-6-methoxy-3- ...