Versatile Synthesis of Acylfuranones by Reaction of Acylketenes with α??Hydroxy Ketones: Application to the One??Step Multicomponent Synthesis of Cadiolide B and …

PA Peixoto, A Boulangé, S Leleu…

Index: Peixoto, Philippe Alexandre; Boulange, Agathe; Leleu, Stephane; Franck, Xavier European Journal of Organic Chemistry, 2013 , # 16 p. 3316 - 3327

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Abstract

Abstract Functionalized acylfuranones have been prepared in a one-step procedure by thermal fragmentation of the corresponding dioxinones in the presence of hydroxy ketones in basic conditions. Multicomponent reactions also occur on addition of an aldehyde as a third reaction partner resulting in an expeditious access to cadiolide B and its analogues.

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