Tetrahedron

Enzyme catalyzed hydroxymethylation of aromatic aldehydes with formaldehyde. Synthesis of hydroxyacetophenones and (S)-benzoins

AS Demir, P Ayhan, AC Igdir, AN Duygu

Index: Demir, Ayhan S.; Ayhan, Peruze; Igdir, A. Cigdem; Duygu, A. Nese Tetrahedron, 2004 , vol. 60, # 31 p. 6509 - 6512

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Citation Number: 32

Abstract

Benzaldehyde lyase from the Pseudomonas Fluorescens catalyzed reaction of aromatic aldehydes with formaldehyde providing 2-hydroxy-1-arylethan-1-one in high yields via an acyloin linkage. Kinetic resolution of rac-benzoins with formaldehyde providing (S)-benzoins and 2-hydroxy-1-arylethan-1-one via C–C bond cleavage and a bond formation reaction.

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