Environmentally friendly and efficient synthesis of various 1, 4-dihydropyridines in pure water

GW Wang, JJ Xia, CB Miao, XL Wu

Index: Wang, Guan-Wu; Xia, Jing-Jing; Miao, Chun-Bao; Wu, Xue-Liang Bulletin of the Chemical Society of Japan, 2006 , vol. 79, # 3 p. 454 - 459

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Citation Number: 52

Abstract

An environmentally friendly and efficient synthesis of a series of 1, 4-dihydropyridines was developed by the practical one-pot reactions of aldehydes with ammonium acetate and 1, 3- dicarbonyl compounds such as alkyl acetoacetate, 5, 5-dimethyl-1, 3-cyclohexanedione, 1, 3- cyclohexanedione, and 2, 4-pentanedione in water without any additives under refluxing conditions.

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