Organic letters

Catalytic (asymmetric) methylene transfer to aldehydes

A Piccinini, SA Kavanagh, PB Connon…

Index: Kavanagh, Sarah A.; Piccinini, Alessandro; Fleming, Eimear M.; Connon, Stephen J. Organic and Biomolecular Chemistry, 2008 , vol. 6, # 8 p. 1339 - 1343

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Citation Number: 24

Abstract

An investigation into the poor activity of sulfides as catalysts for sulfonium-ylide-mediated methylene transfer to aldehydes has indicated that ylide formation is the problematic catalytic cycle step. Alkylation with traditional electrophiles does not proceed with sufficient