Synlett

Solid-phase synthesis of oligosaccharides using novel alkyne-type linkers: Selection of reactive sites on the support by Sonogashira reaction

M Izumi, K Fukase, S Kusumoto

Index: Izumi, Minoru; Fukase, Koichi; Kusumoto, Shoichi Synlett, 2002 , # 9 p. 1409 - 1416

Full Text: HTML

Citation Number: 19

Abstract

Abstract Two new alkyne-type linkers having alkynylmethyloxy moieties were elaborated for solid-phase synthesis of oligosaccharides. A propargyl glycoside-type linker between a sugar residue and a solid support was formed by the Sonogashira reaction of a propargyl glycoside with polymer-supported iodobenzene. A propargyl ester-type linker was also constructed by the same reaction of a 4-(proparygyloxycarbonyl) benzyl glycoside with the ...