Gram-scale synthesis of a glucopyranosylidene-spiro-thiohydantoin and its effect on hepatic glycogen metabolism studied in vitro and in vivo

L Somsák, V Nagy, T Docsa, B Tóth, P Gergely

Index: Somsak, L.Aszlo; Nagy, Veronika; Docsa, Tibor; Toth, B.Ela; Gergely, P.Al Tetrahedron Asymmetry, 2000 , vol. 11, # 2 p. 405 - 408

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Citation Number: 44

Abstract

A high yielding, simple synthesis is described starting from d-glucose to produce gram quantities of a glucopyranosylidene-spiro-thiohydantoin. This compound efficiently inhibited the activity of rat liver glycogen phosphorylase a; moreover, it also activated ...