Canadian journal of chemistry

A simple synthesis of benzimidazole N-oxides from 2-nitroaniline derivatives Scope and limitations

EI Buján, ML Salum

Index: Bujan, Elba I.; Salum, Maria Laura Canadian Journal of Chemistry, 2004 , vol. 82, # 8 p. 1322 - 1327

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Citation Number: 5

Abstract

Several benzimidazole N-oxide derivatives were synthesized in very good yield by heating at reflux the corresponding N-alkyl-2-nitroaniline derivative with NaOH in 60% 1, 4-dioxane water. The effect of substituents on the aromatic ring and amino group on the reaction is ...