Synthesis of (5R, 10S, 11R)-(+)-10, 11-dihydro-5-methyl-5H-dibenzo [a, d] cyclohepten-5, 10-imin-11-ol: a hydroxylated metabolite of MK-0801

RD Larsen, P Davis, EG Corley, PJ Reider…

Index: Larsen, Robert D.; Davis, Paul; Corley, Edward G.; Reider, Paul J.; Rothauser Lamanec, Theresa; Grabowski, Edward J. J. Journal of Organic Chemistry, 1990 , vol. 55, # 1 p. 299 - 304

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Citation Number: 11

Abstract

Introduction The dibenzo [a, d] cycloheptenimine MK-0801 (1c)'p2 has been the focus of much attention because of its potent CNS activity as a noncompetitive N-methybaspartate (NMDA) receptor antag~ nist.~ Excitatory amino acids (eg, glutamate and aspartate) are believed to be responsible for neuronal death that occurs as a result of seizures, cerebral ischemia, or an excess of the NMDA receptors in the brain. This has led to the recent study ...