Asymmetric Organocatalytic Intramolecular Aza??Michael Addition of Enone Carbamates: Catalytic Enantioselective Access to Functionalized 2??Substituted …

…, YC Chen, GB Zhang, ZQ Li, P Chen…

Index: Liu, Jian-Dong; Chen, Ying-Chun; Zhang, Guo-Biao; Li, Zhi-Qiang; Chen, Peng; Du, Ji-Yuan; Tu, Yong-Qiang; Fan, Chun-An Advanced Synthesis and Catalysis, 2011 , vol. 353, # 14-15 p. 2721 - 2730

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Citation Number: 27

Abstract

Abstract The synthetically useful functionalized 2-substituted piperidines containing a lateral ketone group have been strategically accessed via an organocatalytic enantioselective intramolecular aza-Michael addition of enone carbamates, in which a novel internal substrate combination of the enone moiety as Michael acceptor and the carbamate moiety as Michael donor was revealed in asymmetric bifunctional organocatalysis. This ...

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