Asymmetric Aldol Reaction of Glyoxal Catalyzed by Diarylprolinol

Y Hayashi, M Kojima

Index: Hayashi, Yujiro; Kojima, Masahiro ChemCatChem, 2013 , vol. 5, # 10 p. 2883 - 2885

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Citation Number: 8

Abstract

Glyoxal, possessing two conjoined formyl groups, is a synthetically useful reagent that is commercially available as a 39% aqueous solution.[1] If the addition of D2O to commercial aqueous glyoxal is monitored by 1H NMR spectroscopy, several species, including its hydrated form and dimer and trimer species, are observed.[2] Despite these complications, it is clearly an advantage to employ this reagent directly as an aqueous solution in synthetic ...