Tetrahedron Letters

Palladium-catalyzed Negishi α-arylation of alkylsulfones

G Zhou, PC Ting, RG Aslanian

Index: Zhou, Gang; Ting, Pauline C.; Aslanian, Robert G. Tetrahedron Letters, 2010 , vol. 51, # 6 p. 939 - 941

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Citation Number: 27

Abstract

The sulfone is an important organic structural motif in the total synthesis of natural products and biologically active compounds. 1 The sulfonyl group can facilitate the deprotonation of a neighboring carbon atom and the corresponding carbanion can then be used for a variety of transformations. Afterwards, the auxiliary sulfonyl group can be easily removed by reductive desulfonylation. 1b Although several synthetic routes to arylmethylsulfones have been ...