Synthesis of the first selective irreversible inhibitor of neutral sphingomyelinase

C Arenz, A Giannis

Index: Arenz, Christoph; Giannis, Athanassios European Journal of Organic Chemistry, 2001 , # 1 p. 137 - 140

Full Text: HTML

Citation Number: 27

Abstract

Abstract The sphingolipid ceramide is a candidate second messenger assumed to be involved in fundamental processes such as growth control, inflammation and apoptosis. Many aspects of ceramide-mediated processes remain to be clarified, including the question of which of the different sphingomyelinases is critical for the stimulus-induced ceramide production. Selective inhibitors of the sphingomyelinases are useful tools for clarifying the ...