Selective delivery of cytotoxic compounds to cells by the LDL pathway

…, JR Falck, MM McPhaul, M Krieger

Index: Firestone, Raymond A.; Pisano, Judith M.; Falck, J. R.; McPhaul, Michael M.; Krieger, Monty Journal of Medicinal Chemistry, 1984 , vol. 27, # 8 p. 1037 - 1043

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Citation Number: 90

Abstract

Background. There is a constant search for differences between malignant and normal cells that can be exploited in chemotherapy. One such difference that has not yet been utilized is in the rate of metabolism of low-density lipoprotein (LDL). 3 Body cells obtain cholesterol either by de novo synthesis or from LDL, or both. Cancer cells, like all dividing ones, need large amounts of cholesterol because they are making new membrane. Thus it is logical to ...