Covalent inhibition of bacterial quorum sensing

N Amara, R Mashiach, D Amar, P Krief…

Index: Amara, Neri; Mashiach, Roi; Amar, Dotan; Krief, Pnina; Spieser, Stephane A. H.; Bottomley, Matthew J.; Aharoni, Amir; Meijler, Michael M. Journal of the American Chemical Society, 2009 , vol. 131, # 30 p. 10610 - 10619

Full Text: HTML

Citation Number: 115

Abstract

Chemical coordination of gene expression among bacteria as a function of population density is regulated by a mechanism known as 'quorum sensing'(QS). QS in Pseudomonas aeruginosa, an opportunistic pathogen that causes disease in immunocompromised patients, is mediated by binding of the transcriptional activator, LasR, to its ligand, 3-oxo- C12-HSL, leading to population-wide secretion of virulence factors and biofilm formation. ...

Related Articles:

Efficient and scaleable methods for ω-functionalized nonanoic acids: Development of a novel process for azelaic and 9-aminononanoic acids (nylon-6, 9 and nylon-9 …

[Cotarca, Livius; Delogu, Pietro; Nardelli, Alfonso; Maggioni, Paolo; Bianchini, Roberto; Sguassero, Stefano; Alini, Stefano; Dario, Roberto; Clauti, Giuliano; Pitta, Giorgio; Duse, Gianpaolo; Goffredi, Fabrizio Organic Process Research and Development, 2001 , vol. 5, # 1 p. 69 - 76]

Ozonolysis-reductive amination of olefins

[Pollart,K.A.; Miller,R.E. Journal of Organic Chemistry, 1962 , vol. 27, p. 2392 - 2394]

Efficient and scaleable methods for ω-functionalized nonanoic acids: Development of a novel process for azelaic and 9-aminononanoic acids (nylon-6, 9 and nylon-9 …

[Cotarca, Livius; Delogu, Pietro; Nardelli, Alfonso; Maggioni, Paolo; Bianchini, Roberto; Sguassero, Stefano; Alini, Stefano; Dario, Roberto; Clauti, Giuliano; Pitta, Giorgio; Duse, Gianpaolo; Goffredi, Fabrizio Organic Process Research and Development, 2001 , vol. 5, # 1 p. 69 - 76]

Efficient and scaleable methods for ω-functionalized nonanoic acids: Development of a novel process for azelaic and 9-aminononanoic acids (nylon-6, 9 and nylon-9 …

[Cotarca, Livius; Delogu, Pietro; Nardelli, Alfonso; Maggioni, Paolo; Bianchini, Roberto; Sguassero, Stefano; Alini, Stefano; Dario, Roberto; Clauti, Giuliano; Pitta, Giorgio; Duse, Gianpaolo; Goffredi, Fabrizio Organic Process Research and Development, 2001 , vol. 5, # 1 p. 69 - 76]

Thiophene and its homologues as starting compounds for the preparation of aliphatic amino acids

[Gol'dfarb,Ya.L. et al. Tetrahedron, 1962 , vol. 18, p. 21 - 36]

More Articles...