An approach to the Paal–Knorr pyrroles synthesis catalyzed by Sc (OTf) 3 under solvent-free conditions

J Chen, H Wu, Z Zheng, C Jin, X Zhang, W Su

Index: Chen, Jiuxi; Wu, Huayue; Zheng, Zhiguo; Jin, Can; Zhang, Xingxian; Su, Weike Tetrahedron Letters, 2006 , vol. 47, # 30 p. 5383 - 5387

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Citation Number: 154

Abstract

A facile synthesis of N-substituted pyrroles by the Paal–Knorr condensation has been accomplished using a simple procedure. Among different metal triflates screened, 1mol% Sc (OTf) 3 efficiently promoted the reaction to give excellent yield (89–98%) under mild reaction conditions. Additionally, Sc (OTf) 3 could be recovered easily after the reactions and reused without evident loss in activity.