Antibacterial activity of aminals and hemiaminals of pyrazole and imidazole

S Lupsor, F Aonofriesei, M Iovu

Index: Lupsor, Simona; Aonofriesei, Florin; Iovu, Mircea Medicinal Chemistry Research, 2012 , vol. 21, # 10 p. 3035 - 3042,8

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Citation Number: 4

Abstract

Abstract Antibacterial activity of 1, 1′-methylenedipyrazole (AM1), 1-hydroxymethylpyrazole (SAM1), 1, 1′-methylenediimidazole (AM2), and 1-hydroxymethylimidazole (SAM2) has been tested against reference and clinical strains by both difusimetric and broth dilution methods. Overall, the minimal inhibitory concentrations of tested compounds ranged from 180 to 270 μg/ml, while the minimal bactericidal concentrations were between 360 and ...