Studies on the novel anti-staphyloccal compound nematophin

…, F Micheli, P Rodegher, P Seneci, A Zumerle

Index: Kennedy, Gordon; Viziano, Monica; Winders, John Alexander; Cavallini, Palmina; Gevi, Monica; Micheli, Fabrizio; Rodegher, Pamela; Seneci, Pierfausto; Zumerle, Aurelia Bioorganic and Medicinal Chemistry Letters, 2000 , vol. 10, # 15 p. 1751 - 1754

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Citation Number: 13

Abstract

A number of analogues of the recently described compound nematophin were prepared and studied for antibacterial activity. The 2-phenyl derivative was found to exhibit exceptional activity against methicillin resistant Staphylococcus aureus (MRSA) whereas the isosteric benzimidazole analogue was much less active.