Screening Multicomponent Reactions for X-Linked Inhibitor of Apoptosis-Baculoviral Inhibitor of Apoptosis Protein Repeats Domain Binder

I Monfardini, JW Huang, B Beck, JF Cellitti…

Index: Monfardini, Ilaria; Huang, Jui-Wen; Beck, Barbara; Cellitti, Jason F.; Pellecchia, Maurizio; Domling, Alexander Journal of Medicinal Chemistry, 2011 , vol. 54, # 3 p. 890 - 900

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Citation Number: 12

Abstract

We report a second example of a general reaction screening approach to discover low molecular weight inhibitors of protein protein interactions. On the basis of the known pharmacophore model of SMAC mimetics, we predicted several inhibitors based on four different multicomponent reactions. The predicted inhibitors were subsequently synthesized, tested, and found to bind to the antiapoptotic protein X-linked inhibitor of apoptosis protein ...