IMPROVED SYNTHESIS OF N-ALKYL-ASPARTIC ACIDS

R Laliberte, L Berlinguet

Index: Laliberte,R.; Berlinguet,L. Canadian Journal of Chemistry, 1962 , vol. 40, p. 163 - 165

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Citation Number: 8

Abstract

N-Alkyl-aspartic acids can now be prepared readily by nucleophilic addition of primary amines to the double bond of inonomethyl maleate according to a technique first described by Zilkha and Bachi (1). During the preparation of some N-alkyl-aspartic acids, we found that triethylamine could advantageously replace pyridine as solvent and catalyst. The yields are about 200jo higher and the isolation of a much purer product is possible owing to the absence of colored ...