Total Synthesis of (.+-.)-Dragmacidin: A Cytotoxic Bis (indole) alkaloid of Marine Origin

B Jiang, JM Smallheer, C Amaral-Ly…

Index: Jiang; Smallheer; Amaral-Ly; Wuonola Journal of Organic Chemistry, 1994 , vol. 59, # 22 p. 6823 - 6827

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Citation Number: 77

Abstract

During the past years, a large number of marine natural products containing the indole nucleus have been isolated. The various structures of these indole alkaloids and their varied biological activities have been recently reviewed. l Although many marine natural products contain indole, derived biosynthetically from tryptamine, few contain an unoxidized piperazine ring between differently-substituted indole residues such as is found in the ...