A convenient synthesis of lubeluzole and its enantiomer: evaluation as chemosensitizing agents on human ovarian adenocarcinoma and lung carcinoma cells

…, A Carocci, A Catalano, A Carrieri, C Franchini…

Index: Cavalluzzi, Maria Maddalena; Viale, Maurizio; Bruno, Claudio; Carocci, Alessia; Catalano, Alessia; Carrieri, Antonio; Franchini, Carlo; Lentini, Giovanni Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 17 p. 4820 - 4823

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Citation Number: 7

Abstract

Abstract Lubeluzole, a neuroprotective anti-ischemic drug, and its enantiomer were prepared following a convenient procedure based on hydrolytic kinetic resolution. The ee values were> 99% and 96%, respectively, as assessed by HPLC analysis. The chemosensitizing effects of both enantiomers were evaluated in combination with either doxorubicin (human ovarian adenocarcinoma A2780 cells) or paclitaxel (human lung ...