Regiocontrolled Synthesis of 1, 2??Diaryl??1H??imidazoles by Palladium??and Copper??Mediated Direct Coupling of 1??Aryl??1H??imidazoles with Aryl Halides under …

F Bellina, S Cauteruccio, L Mannina…

Index: Bellina, Fabio; Cauteruccio, Silvia; Mannina, Luisa; Rossi, Renzo; Viel, Stephane European Journal of Organic Chemistry, 2006 , # 3 p. 693 - 703

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Citation Number: 55

Abstract

Abstract A large variety of 1, 2-diaryl-1H-imidazoles, including a selective COX-2 inhibitor, have been regioselectively synthesised in moderate to high yields by direct coupling of 1- aryl-1H-imidazoles with aryl iodides or bromides in DMF in the presence of CsF and catalytic amounts of Pd (OAc) 2 under ligandless conditions. A possible mechanism for this new highly regioselective C-2 arylation reaction, involving the formation of an organocopper (I) ...

Synthesis, structure-activity relationships at the GABAA receptor in rat brain, and differential electrophysiological profile at the recombinant human GABAA receptor of …

[Asproni, Battistina; Talani, Giuseppe; Busonero, Fabio; Pau, Amedeo; Sanna, Sebastiano; Cerri, Riccardo; Mascia, Maria Paola; Sanna, Enrico; Biggio, Giovanni Journal of Medicinal Chemistry, 2005 , vol. 48, # 7 p. 2638 - 2645]

Copper-catalyzed CuAAC/intramolecular C–H arylation sequence: Synthesis of annulated 1, 2, 3-triazoles

[Jeyachandran, Rajkumar; Potukuchi, Harish Kumar; Ackermann, Lutz Beilstein Journal of Organic Chemistry, 2012 , vol. 8, p. 1771 - 1777,7]

Synthesis, structure-activity relationships at the GABAA receptor in rat brain, and differential electrophysiological profile at the recombinant human GABAA receptor of …

Regiocontrolled Synthesis of 1, 2??Diaryl??1H??imidazoles by Palladium??and Copper??Mediated Direct Coupling of 1??Aryl??1H??imidazoles with Aryl Halides under …

Abstract

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