Carboxylate??Directed Tandem Functionalisations of α, β??Dihaloalkenoic Acids with 1??Alkynes: A Straightforward Access to (Z)??Configured, α, β??Substituted γ?? …

…, L Commeiras, JL Parrain, A Duchêne…

Index: Inack Ngi, Samuel; Cherry, Khalil; Heran, Virginie; Commeiras, Laurent; Parrain, Jean-Luc; Duchene, Alain; Abarbri, Mohamed; Thibonnet, Jerome Chemistry - A European Journal, 2011 , vol. 17, # 49 p. 13692 - 13696

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Citation Number: 6

Abstract

Butenolides 1 represent an important class of naturally occurring lactones. Among them, 3- substituted and 3, 4-substituted 5-ylidene-5H-furan-2-ones are of continuous interest as synthetic targets, and some of the substances presenting these moieties display a wide range of biological activities. Very simple examples of these substances include molecules, such as tetrenolin,[1] which displays antibiotic activity, the cytotoxic and herbicidal ...

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