Synthesis and biological evaluation of benzo [d] imidazole derivatives as potential anti-cancer agents

HM Alkahtani, AY Abbas, S Wang

Index: Alkahtani, Hamad M.; Abbas, Abdullahi Y.; Wang, Shudong Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 3 p. 1317 - 1321

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Citation Number: 24

Abstract

We herein report the synthesis, biological activity and structure–activity relationship of derivatives of 5, 6-dichloro-1-β-d-ribofuranosylbenzimidazole and benzo [d] imidazole. A lead compound 6o demonstrates potent anti-proliferative activity and the ability to induce cancer cell apoptosis.