Propargyl-substituted phosphonocarboxylates: efficient synthesis and application to click chemistry

OI Artyushin, SN Osipov, GV Röschenthaler…

Index: Artyushin, Oleg I.; Osipov, Sergey N.; Roeschenthaler, Gerd-Volker; Odinets, Irina L. Synthesis, 2009 , # 21 p. 3579 - 3588

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Citation Number: 13

Abstract

Abstract An efficient pathway for the selective preparation of monopropargyl-substituted phosphonocarboxylate (PC) has been developed via the addition of sodium acetylenide to ethylidenephosphonate. The reaction works perfectly on multi-gram scales. The synthesis of the corresponding methyl (propargyl)-, trifluoromethyl (propargyl)-, and dipropargyl- substituted derivatives was elaborated based on direct alkylation of either the ...