1, 8-Naphthyridines VI. Synthesis and anti-inflammatory activity of 5-(alkylamino)-N, N-diethyl [1, 2, 4] triazolo [4, 3-a][1, 8] naphthyridine-6-carboxamides with a new …

M Di Braccio, G Grossi, G Roma, D Piras…

Index: Di Braccio, Mario; Grossi, Giancarlo; Roma, Giorgio; Piras, Daniela; Mattioli, Francesca; Gosmar, Marzia European Journal of Medicinal Chemistry, 2008 , vol. 43, # 3 p. 584 - 594

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Citation Number: 19

Abstract

On the basis of the good anti-inflammatory properties shown by the 9-alkyl-N, N-dialkyl-5- (alkylamino)[1, 2, 4] triazolo [4, 3-a][1, 8] naphthyridine-6-carboxamides 1, a series of analogues of such compounds, in which the 9-alkyl substituent was replaced by an ester or amide group (compounds 3a–i), was prepared and tested (inhibition of carrageenan- induced paw edema in the rat). Also two 5-(N-alkyl, N-acylamino) derivatives (compounds ...

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