Synthesis and biological evaluation of 2-aminothiazole derivatives as antimycobacterial and antiplasmodial agents

F Mjambili, M Njoroge, K Naran, C De Kock…

Index: Mjambili, Faith; Njoroge, Mathew; Naran, Krupa; De Kock, Carmen; Smith, Peter J.; Mizrahi, Valerie; Warner, Digby; Chibale, Kelly Bioorganic and Medicinal Chemistry Letters, 2014 , vol. 24, # 2 p. 560 - 564

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Citation Number: 14

Abstract

Abstract A series of compounds derived from the 2-amino-4-(2-pyridyl) thiazole scaffold was synthesized and tested for in vitro antimycobacterial activity against the Mycobacterium tuberculosis H37Rv strain, antiplasmodial activity against the chloroquine sensitive NF54 Plasmodium falciparum strain and cytotoxicity on a mammalian cell line. Optimal antimycobacterial activity was found with compounds with a 2-pyridyl ring at position 4 of ...