Efficient and regioselective synthesis of 5-hydroxy-2-isoxazolines: versatile synthons for isoxazoles, β-lactams, and γ-amino alcohols

S Tang, J He, Y Sun, L He, X She

Index: Tang, Shibing; He, Jinmei; Sun, Yongquan; He, Liuer; She, Xuegong Journal of Organic Chemistry, 2010 , vol. 75, # 6 p. 1961 - 1966

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Citation Number: 36

Abstract

An efficient and highly regioselective protocol was developed for the preparation of 5- hydroxy-2-isoxazolines, which have been proved to be versatile synthons for isoxazles, β- hydroxy oximes, and γ-amino alcohols. β-Lactams, commonly embedded in the skeletons of bioactive natural products, were also synthesized in two steps from β-hydroxy oximes, providing a new strategy for the synthesis of this kind of compounds.