Efficient and regioselective functionalization of imidazo [1, 2-b] pyridazines via palladium-catalyzed cross-coupling reaction and SN Ar

…, J Koubachi, S El Kazzouli, S Berteina-Raboin…

Index: El Akkaoui; Koubachi; El Kazzouli; Berteina-Raboin; Mouaddib; Guillaumet Tetrahedron Letters, 2008 , vol. 49, # 15 p. 2472 - 2475

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Citation Number: 11

Abstract

The synthesis of 3, 6-disubstituted-2-phenylimidazo [1, 2-b] pyridazine derivatives by palladium cross-coupling and SNAr reactions is described. Sonogashira and Stille cross- coupling reactions were investigated to introduce alkynyl, alkenyl, and aryl at the 3-position of imidazo [1, 2-b] pyridazines. Then, at the 6-position, palladium-catalyzed N-arylation and direct SNAr were used to introduce amines and alcohols.