In situ Catalytic Generation of Allylcopper Species for Asymmetric Allylation: Toward 1H??Isochromene Skeletons

J Kawai, PK Chikkade, Y Shimizu…

Index: Kawai, Junya; Chikkade, Prasanna Kumara; Shimizu, Yohei; Kanai, Motomu Angewandte Chemie - International Edition, 2013 , vol. 52, # 28 p. 7177 - 7180

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Citation Number: 17

Abstract

Asymmetric allylation of carbonyl groups has been extensively studied because of the high versatility of enantiomerically enriched homoallylic alcohols.[1] There are four main methods for catalytic asymmetric carbonyl allylation: a) using allylmetal species (such as allyl tin, allyl silicon, and allyl boron reagents),[2] b) using the catalytic variant of the Nozaki–Hiyama reaction,[3] c) using reductive generation of nucleophilic π-allyl palladium from allylic ...