Vilsmeier–Haack Bromination of Aromatic Compounds with KBr and N-Bromosuccinimide Under Solvent-Free Conditions

A Chakradhar, R Roopa, KC Rajanna…

Index: Chakradhar; Roopa; Rajanna; Saiprakash Synthetic Communications, 2009 , vol. 39, # 10 p. 1817 - 1824

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Citation Number: 17

Abstract

Abstract Bromination of aromatic hydrocarbons is triggered by Vilsmeier–Haack reagent [N, N-dimethyl formamide (DMF–POCl3 system)] in the presence of KBr or N-bromosuccinimide (NBS) under solvent-free conditions by grinding the reactants in a mortar with a pestle. The reactions afforded corresponding bromo derivatives in very good yield with high regioselectivity. The results are comparable with those obtained under reflux conditions.