Tetrahedron letters

A thermally-cleavable linker for solid-phase synthesis

KA Keller, J Guo, S Punna, MG Finn

Index: Keller, Keith A.; Guo, Jianhua; Punna, Sreenivas; Finn Tetrahedron Letters, 2005 , vol. 46, # 7 p. 1181 - 1184

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Citation Number: 30

Abstract

Oxabicyclo [2.2. 1] norbornenes constitute a convenient and readily cleaved linker for solid- phase organic synthesis. A simple and inexpensive furfuryl-substituted resin has been shown to capture and release maleimide dienophiles under conditions compatible with intermediate synthetic steps. The synthesis of β-amino,-thiophenoxy, and-hydrazino alcohols by epoxide ring opening, and maleimide-functionalized Leu-enkephalin by ...

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