9-[(Phosphonoalkyl) benzyl] guanines. Multisubstrate analog inhibitors of human erythrocyte purine nucleoside phosphorylase

JL Kelley, JA Linn, EW McLean…

Index: Kelley; Linn; McLean; Tuttle Journal of Medicinal Chemistry, 1993 , vol. 36, # 22 p. 3455 - 3463

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Citation Number: 31

Abstract

A series of 9-[(phosphonoalkyl) benzyllguanines was synthesized and tested for inhibition of human erythrocyte purine nucleoside phosphorylase (PNPase). Inhibitors of PNPase should be T-cell selective, immunosuppressive agents with potential clinical utility in the treatment of a wide variety of disorders in which T-lymphocytes are pathogenic. An initial set of six analogues of the weak PNPase inhibitor 9-benzylguanine (2) contained a phosphonic ...