Experimental chemotherapy of typhus Anti-rickettsial action of p-sulphonamidobenzamidine and related compounds

CH Andrewes, H King, J Walker

Index: Andrewes; King; Walker Proceedings of the Royal Society of London, Series B: Biological Sciences, 1946 , vol. 133, p. 20,30

Full Text: HTML

Citation Number: 26

Abstract

Abstract The discovery of the pronounced anti-rickettsial activity of p- sulphonamidobenzamidine on experimental typhus infections in mice has led to a search for compounds of enhanced therapeutic action. A large number of compounds have been prepared in development of the sulphonamido-amidine structure, but anti-rickettsial activity has been found to be confined to about a dozen substances intimately related to p- ...