Syntheses of sphingosine-1-phosphate stereoisomers and analogues and their interaction with EDG receptors
HS Lim, YS Oh, PG Suh, SK Chung
Index: Lim, Hyun Suk; Oh, Yong Seok; Suh, Pann Ghill; Chung, Sung Kee Bioorganic and medicinal chemistry letters, 2003 , vol. 13, # 2 p. 237 - 240
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Citation Number: 26
Abstract
Sphingosine-1-phosphate (S1P) is considered to be an important regulator of diverse biological processes acting as a natural ligand to EDG receptors. As a preliminary study to develop potent and selective agonist and antagonist for EDG receptors, we report synthesis of S1P stereoisomers and analogues and their binding affinities to EDG-1,-3, and-5.
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