Total synthesis of ouabagenin and ouabain

H Zhang, M Sridhar Reddy, S Phoenix…

Index: Zhang, Hongxing; Sridhar Reddy, Maddi; Phoenix, Serge; Deslongchamps, Pierre Angewandte Chemie - International Edition, 2008 , vol. 47, # 7 p. 1272 - 1275

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Citation Number: 49

Abstract

Ouabain (1a), a cardioactive glycoside isolated from the bark of the African ouabio tree (Acokanthera ouabio) by Arnaud in 1888),[1] has received considerable attention since it was discovered that an ouabain-like compound occurs naturally in mammals and acts as an endogenous digitalis as proposed by Szent–Gyorgyi.[2] After some debate, it was established that the endogenous and plant derived ouabain are in fact identical.[3] ...