Synthesis and biological activity of C-terminal fragments of vasopressin

…, VP Martinovich, AB Usenko, LK Slobodchikova…

Index: Golubovich, V. P.; Martinovich, V. P.; Usenko, A. B.; Slobodchikova, L. K.; Titov, S. A.; Ashmarin, I. P. Pharmaceutical Chemistry Journal, 1988 , vol. 22, # 6 p. 440 - 444 Khimiko-Farmatsevticheskii Zhurnal, 1988 , vol. 22, # 6 p. 675 - 679

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Citation Number: 4

Abstract

Ina study of vasopressin proteolysis in cerebral synaptic membranes several linear fragments of this hormone which contain a cysteine residue were discovered [5]. It turned out that the peptides of the 4-8 and 4-9 sequence that contain a disulfide bond exhibit a very high level of neurotropic activity which exceeds by hundreds of times the activity of the whole hormone in tests involving a conditional passive avoidance reflex [6]. It is recognized that ...