Palladium-catalyzed coupling reactions of (ArCH 2) Ti (Oi-Pr) 3 with aromatic or heteroaromatic bromides

ST Chang, Q Li, RT Chiang, HM Gau

Index: Chang, Shu-Ting; Li, Qinghan; Chiang, Ruei-Tang; Gau, Han-Mou Tetrahedron, 2012 , vol. 68, # 21 p. 3956 - 3962

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Citation Number: 8

Abstract

Three benzyltitanium compounds of (ArCH2) Ti (Oi-Pr) 3 (Ar= Ph (1a), 4-MeOC6H4 (1b), 4- FC6H4 (1c)) were prepared and used as benzyl nucleophiles for coupling reactions with aromatic or heteroaromatic bromides. The simple catalytic system of 1 mol% Pd (OAc) 2 and 2 mol% PCy3 worked efficiently for a wide variety of aromatic bromides, producing diarylmethanes in good to excellent yields of up to 96%. Coupling reactions of hindered ...