Scandium (III) triflate-catalyzed Friedel-Crafts alkylation reactions

T Tsuchimoto, K Tobita, T Hiyama…

Index: Tsuchimoto, Teruhisa; Tobita, Kazuo; Hiyama, Tamejiro; Fukuzawa, Shin-Ichi Journal of Organic Chemistry, 1997 , vol. 62, # 20 p. 6997 - 7005

Full Text: HTML

Citation Number: 177

Abstract

The Sc (OTf) 3-catalyzed Friedel-Crafts alkylation reaction with an alcohol, an arenecarbaldehyde or an arenecarbaldehyde acetal as the alkylating agent affords a diarylmethane or an allylbenzene derivative highly selectively. The salient feature of this reaction is that only a catalytic amount of Sc (OTf) 3 can effect the reaction. Furthermore, Sc (OTf) 3 is recoverable and reusable after the synthetic reaction. The Sc (OTf) 3-catalyzed ...