Synthesis and pharmacological activity of some new pyridazinones

…, G Strappaghetti, A Codagnone, R Scapicchi…

Index: Corsano, S; Strappaghetti, G; Codagnone, A; Scapicchi, R; Marucci, G European Journal of Medicinal Chemistry, 1992 , vol. 27, # 5 p. 545 - 549

Full Text: HTML

Citation Number: 7

Abstract

Abstract The synthesis of a series of piperazinyl-pyridazinones is reported. The blocking activity of these compounds was determined on the pre-and postsynaptic α-adrenoreceptors of isolated rat vas deferens. For compounds 7, 17 and 18, the hypotensive activity was also evaluated.