Parallel sheet structure in cyclopropane γ-peptides stabilized by C–H⋯ O hydrogen bonds

MKN Qureshi, MD Smith

Index: Qureshi, M. Khurram N.; Smith, Martin D. Chemical Communications, 2006 , # 48 p. 5006 - 5008

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Citation Number: 39

Abstract

Hydrogen bonding is ubiquitous in biological systems; its role encompasses the reactivity and specificity of enzymatic reactions, the stability of proteins, and the formation and stabilization of secondary structural elements. 1 Although the factors influencing the folding of proteins are manifold, hydrogen bonding between NH and C O functional groups plays a pivotal role. The design of non-natural oligomeric species that emulate protein-like folding into secondary ...