Tetrahedron letters

An expedient method for the synthesis of 6-substituted uracils under microwave irradiation in a solvent-free medium

I Devi, PJ Bhuyan

Index: Devi, Ipsita; Bhuyan, Pulak J. Tetrahedron Letters, 2005 , vol. 46, # 34 p. 5727 - 5729

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Citation Number: 44

Abstract

Condensation of malonic acid 1 and ureas 2a–f proceeds smoothly in the presence of acetic anhydride 3 under microwave irradiation in solvent-free conditions to give 6-hydroxy-uracils 4 in excellent yields. Under identical conditions, the condensation of cyanoacetic acid 5 and ureas 2a, b, g and h in the presence of acetic anhydride 3, followed by cyclization in the presence of sodium hydroxide affords 6-amino-uracils 6 in high yields. The work-up ...

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