Deaza analogues of adenosine as inhibitors of blood platelet aggregation

…, G Cristalli, P Franchetti, M Grifantini…

Index: Antonini; Cristalli; Franchetti; Grifantini; Martelli; Petrelli Journal of Pharmaceutical Sciences, 1984 , vol. 73, # 3 p. 366 - 369

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Citation Number: 38

Abstract

Abstract A number of deaza analogues of adenosine were prepared and tested as inhibitors of platelet aggregation induced by ADP and collagen to investigate the structure-activity relationships in this class of nucleoside analogues. The results showed that the presence of a 6-amino group and nitrogen atoms at positions 3 and 7 of the purine moiety are required for inhibitory activity.

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