In vitro SAR of pyrrolidine-containing histamine H 3 receptor antagonists: Trends across multiple chemical series

DL Nersesian, LA Black, TR Miller, TA Vortherms…

Index: Bioorganic and Medicinal Chemistry Letters, , vol. 18, # 1 p. 355 - 359

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Citation Number: 16

Abstract

... Bioorganic & Medicinal Chemistry Letters. ... The results thus support the hypothesis that 2-methylpyrrolidine generally enhances in vitro potency across diverse chemical classes, and that the (R)-configuration is superior to the (S)-configuration. ...