Cobalt??Catalyzed C–N Bond??Forming Reaction between Chloronitrobenzenes and Secondary Amines

G Toma, R Yamaguchi

Index: Toma, Gabriel; Yamaguchi, Ryohei European Journal of Organic Chemistry, 2010 , # 33 p. 6404 - 6408

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Citation Number: 8

Abstract

Abstract Cyclic secondary amines react with mono-or dichloronitrobenzene in the presence of a catalytic amount of cobalt (II) chloride. Phosphane ligands are beneficial for the reaction, although the bite-angle effect was not strong. The nitro-substituted tertiary amines formed are important as bioactive compounds and can also be intermediates for the synthesis of substituted anilines. This work represents the first cobalt-catalyzed approach to C–N bond ...